| 货号 | 18147-100mg |
| 描述 | Cytidine 5-triphosphate (CTP) is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases. In the formation of phosphatidylcholine (PC), CTP reacts with phosphocholine, via CTP:phosphocholine cytidylyltransferases, to produce CDP-choline and diphosphate.1,2 This is the rate-limiting step in PC synthesis and, as a pivotal step in cell proliferation, can be important in cancer.3 CTP also interacts with N-acylneuraminate, in a reaction mediated by N-acylneuraminate cytidylyltransferase, to generate an intermediate that is required for sialylation, namely CMP-N-acylneuraminic acid.4 |
| 别名 | CTP;NSC 20261; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Li, Z., and Vance, D.E. Phosphatidylcholine and choline homeostasis. Journal of Lipid Research 49, 1187-1194 (2008). 2.Lagace, T.A., and Ridgway, N.D. The role of phospholipids in the biological activity and structure of the endoplasmic reticulum. Biochim.Biophys.Acta. 1833, 2499-2510 (2013). 3.Arsenault, D.J.,Yoo, B.H.,Rosen, K.V., et al. ras-Induced up-regulation of CTP:phosphocholine cytidyltransferase a contributes to malignant transformation of intestinal epithelial cells. The Journal of Biological Chemisty 288(1), 633-643 (2013). 4.Vionnet, J.,Concepcion, N.,Warner, T., et al. Purification of CMP-N-acetylneuraminic acid synthetase from bovine anterior pituitary glands. Glycobiology 9(5), 481-487 (1999). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 527.1 |
| 分子式 | C9H14N3O14P3 • 2Na |
| CAS号 | 36051-68-0 |
| 稳定性 | ≥ 2 years |
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