| 货号 | 18137-100mg |
| 描述 | UDP is the diphosphate of the nucleoside uridine. It is a specific agonist of the P2Y purinoceptor P2Y6(EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstriction.1,2,3,4,5,6 UDP also acts as an antagonist of P2Y14, whose agonists include UDP-glucose (Item No. 15602), UDP-galactose, and UDP-glucuronic acid.1,2 |
| 别名 | Uridine-5-diphosphate; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jacobson, K.A.,Ivanov, A.A.,de Castro, S., et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 5(1), 75-89 (2009). 2.Abbracchio, M.P.,Burnstock, G.,Boeynaems, J.M., et al. International Union of Pharmacology LVIII: Update on the P2Y G protein-coupled nucleotide receptors: From molecular mechanisms and pathophysiology to therapy. Pharmacological Reviews 58(3), 281-341 (2006). 3.Garcia, R.A.,Yan, M.,Search, D., et al. P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development. PLoS One 9(10), 1-13 (2014). 4.Inoue, K. UDP facilitates microglial phagocytosis through P2Y6 receptors. Cell Adhesion & Migration 1(3), 131-132 (2007). 5.Besada, P.,Shin, D.H.,Costanzi, S., et al. Structure-activity relationships of uridine 5-diphosphate analogues at the human P2Y6 receptor. Journal of Medicinal Chemistry 49(18), 5532-5543 (2006). 6.Mitchell, C.,Syed, N.,Tengah, A., et al. Identification of contractile P2Y1, P2Y6, and P2Y12 receptors in rat intrapulmonary artery using selective ligands. Journal of Pharmacology and Experimental Therapeutics 343(3), 755-762 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 448.1 |
| 分子式 | C9H12N2O12P2 • 2Na |
| CAS号 | 27821-45-0 |
| 稳定性 | ≥ 2 years |
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