| 货号 | 18135-5g |
| 描述 | Inosine-5-monophosphate (IMP) is a substrate of IMP dehydrogenase (IMPDH), a NAD+-dependent enzyme that generates xanthosine monophosphate. This is a rate-limiting step in the generation of guanosine monophosphate, which is important for DNA, RNA, and glycoprotein synthesis. Inhibitors of IMPDH, including ribavirin (Item No. 16757) and mycophenolate mofetil (Item No. 13988), have potential applications as antiviral and anti-cancer drugs.1,2,3 5-Ribonucleosides, including IMP, are also involved in potentiating the umami taste sensation.4 |
| 别名 | IMP;Inosinic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Watkins, W.J.,Chen, J.M.,Cho, A., et al. Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH. Bioorganic & Medicinal Chemistry Letters 16(13), 3479-3483 (2006). 2.Naik, G.S., and Tyagi, M.G. A pharmacological profile of ribavirin and monitoring of its plasma concentration in chronic hepatitis C infection. J.Clin.Exp.Hepatol. 2, 42-54 (2012). 3.Borden, K.L.B., and Culjkovic-Kraljacic, B. Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond? Leukemia and Lymphoma 51(10), 1805-1815 (2010). 4.Kinnamon, S.C. Umami taste transduction mechanisms. American Journal of Clinical Nutrition 90(suppl), 753S-755S (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 536.3 |
| 分子式 | C10H11N4O8P • 2Na [8H2O] |
| CAS号 | 20813-76-7 |
| 稳定性 | ≥ 2 years |
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