ML167
货号：
18098-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18098-1mg |
| 描述 | The Cdc2-like kinases (Clks) and the dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are involved in regulating gene splicing. Clks phosphorylate serine/arginine-rich proteins, which are a major component of the spliceosome, whereas DYRKs interact with and activate splicing factors. ML167 is a selective, ATP-competitive inhibitor of Clk4 with an IC50 value of 136 nM.1 It is more than 10-fold less active against the closely related kinases Clk1-3, DYRK1A, and DYRK1B (IC50s = 1.5, 1.6, >10, >10, and 4.4 µM, respectively), and minimally active against a panel of other kinases.1 |
| 别名 | CID 44968231; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rosenthal, A.S.,Tanega, C.,Shen, M., et al. An inhibitor of the Cdc2-like kinase 4 (Clk4). Probe Reports from the NIH Molecular Libraries Program (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 335.4 |
| 分子式 | C19H17N3O3 |
| CAS号 | 1285702-20-6 |
| 稳定性 | ≥ 2 years |
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