JNK Inhibitor XVI
货号：
18096-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18096-1mg |
| 描述 | c-Jun N-terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens. JNK inhibitor XVI is a selective, irreversible JNK inhibitor (IC50s = 4.67, 18.7, and 0.98 nM for JNK1, 2, and 3, respectively) that prevents phosphorylation of c-Jun in A375 and HeLa cells with EC50 values of 338 and 486 nM, respectively.1 It has been shown to inhibit JNK kinase activity by a mechanism that depends on covalent modification of cysteine116 in the ATP-binding motif.1 This compound has been used to explore the role of JNK in mediating cancer cell death.2,3 |
| 别名 | JNK-IN-8;c-Jun N-terminal Kinase Inhibitor XVI; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhang, T.,Inesta-Vaquero, F.,Niepel, M., et al. Discovery of potent and selective covalent inhibitors of JNK. Chemistry & Biology 19(1), 140-154 (2012).
2.Li, Q.,Song, X.m.,Ji, Y.y., et al. The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro. Biochem.Bioph.Res.Commun. 440(4), 701-706 (2013).
3.Fallahi-Sichani, M.,Moerke, N.J.,Niepel, M., et al. Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis. Mol.Syst.Biol. 11, 797 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 507.6 |
| 分子式 | C29H29N7O2 |
| CAS号 | 1410880-22-6 |
| 稳定性 | ≥ 2 years |
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