DDR1-IN-1 (hydrate)
货号：
18092-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18092-1mg |
| 描述 | The discoidin domain receptor (DDR) tyrosine kinases are activated by matrix collagens and are important for cell proliferation, differentiation, adhesion, migration, and invasion. DDR1-IN-1 binds to DDR1 and inhibits DDR1 autophosphorylation with an IC50 value of 105 nM and an EC50 value of 87 nM.1,2 It demonstrates weaker inhibition for DDR2 (IC50 = 413 nM) and has a good selectivity profile against a panel of 451 kinases.1 DDR-IN-1 has been shown to inhibit colorectal cancer cell lines when used in combination with the PI3K/mTOR inhibitor, GSK2126458 (Item No. 17377).1 |
| 别名 | Discoidin Domain Receptor 1-IN-1; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kim, H.G.,Tan, L.,Weisberg, E.L., et al. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS Chem Biol. 8, 2145-2150 (2013).
2.Canning, P.,Tan, L.,Chu, K., et al. Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors. Journal of Molecular Biology 426(13), 2457-2470 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 566.1 |
| 分子式 | C30H31F3N4O3 • 0.75H2O |
| 稳定性 | ≥ 2 years |
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