PD 153035
货号：
18080-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18080-1mg |
| 描述 | PD 153035 is a potent, reversible inhibitor of EGFR kinase (Ki = 5.2 pM; IC50 = 29 pM).1 It less effectively inhibits HER2 (IC50 = 2.3 µM) and has little effect on several other receptor and non-receptor tyrosine kinases.1 PD 153035 has been shown to rapidly suppress autophosphorylation of EGFR in fibroblasts and human epidermoid carcinoma cells, as well as to selectively block EGF-mediated cellular processes, including mitogenesis and early gene expression.2,3 |
| 别名 | AG-1517;NSC 669364;SU 5271; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fry, D.W.,Kraker, A.J.,McMichael, A., et al. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 265(5175), 1093-1095 (1994).
2.Bos, M.,Mendelsohn, J.,Kim, Y.M., et al. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clinical Cancer Research 3(11), 2099-2106 (1997).
3.Rae, J.M., and Lippman, M.E. Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors. Breast Cancer Research and Treatment 83(2), 99-107 (2004).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 360.2 |
| 分子式 | C16H14BrN3O2 |
| CAS号 | 153436-54-5 |
| 稳定性 | ≥ 2 years |
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