Pyridostatin
货号：
18013-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18013-1mg |
| 描述 | Pyridostatin is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. It can compete for binding with the telomere-associated proteins and induce telomerase dysfunction. Pyridostatin induces DNA damage and cell cycle arrest (Kd = 490 nM) and has been shown to target the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rodriguez, R.,Miller, K.M.,Forment, J.V., et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat. Chem. Biol. 8(3), 301-310 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 596.6 |
| 分子式 | C31H32N8O5 |
| CAS号 | 1085412-37-8 |
| 稳定性 | ≥ 2 years |
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