LDN-214117
货号：
18006-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18006-1mg |
| 描述 | Bone morphogenetic proteins (BMPs) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation. Activation of BMP type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. LDN-214117 is a selective BMP type I receptor kinase ALK1 and ALK2 inhibitor (IC50s = 24 nM for each).1 It demonstrates preference for ALK1 and ALK2 over ALK3 (IC50 = 1.17 µM) and other related activin and TGF-β type I receptors (IC50s = 3, 0.1, and 16 µM for ALK5, BMP6, and TGF-β, respectively).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mohedas, A.H.,Wang, Y.,Sanvitale, C.E., et al. Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. Journal of Medicinal Chemistry 59(19), 7900-7915 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 419.5 |
| 分子式 | C25H29N3O3 |
| CAS号 | 1627503-67-6 |
| 稳定性 | ≥ 2 years |
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