| 货号 | 17973-1mg |
| 描述 | Secreted phospholipase A2(sPLA2) isoforms are low molecular weight, millimolar calcium-dependent enzymes that hydrolyze the fatty acid from the sn-2 position of membrane phospholipids.1 Group IIA sPLA2, also known as sPLA2IIA and non-pancreatic sPLA2, has roles in the regulation of eicosanoid synthesis and may modulate inflammatory signaling.1,2 LY311727 is an inhibitor of Group IIA sPLA2(IC50 = 0.47 µM) that interacts with the active site of the enzyme in a non-covalent manner.2,3 It shows greater than 1,500-fold selectivity over pancreatic sPLA2 (Group IB sPLA2).3 LY311727 is commonly used to distinguish the actions of Group IIA sPLA2 from those of other sPLA2 isoforms in biological systems.4,5,6,7 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Burke, J.E., and Dennis, E.A. Phospholipase A2 structure/function, mechanism, and signaling. Journal of Lipid Research 50, S237-S242 (2009). 2.Dong, C.Z.,Romieu, A.,Heymans, F., et al. Total direct chemical synthesis and biological activities of human group IIA secretory phospholipase A2. Biochemistry Journal 365, 505-511 (2002). 3.Schevitz, R.W.,Bach, N.J.,Carlson, D.G., et al. Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2. Nature Structural Biology 2(6), 458-465 (1995). 4.Hurt-Camejo, E.,Andersen, S.,Standal, R., et al. Localization of nonpancreatic secretory phospholipase A2 in normal and atherosclerotic arteries. Activity of the isolated enzyme on low-density lipoproteins. Arteriosclerosis, Thrombosis, and Vascular Biology 17, 300-309 (1997). 5.Thommesen, L.,Sjursen, W.,Gåsvik, K., et al. Selective inhibitors of cytosolic or secretory phospholipase A2 block TNF-induced activation of transcription factor nuclear factor-κB and expression of ICAM-1. Journal of Immunology 161, 3421-3430 (1998). 6.Shinohara, H.,Balboa, M.A.,Johnson, C.A., et al. Regulation of delayed prostaglandin production in activated P388D1 macrophages by group IV cytosolic and group V secretory phospholipase A2s. The Journal of Biological Chemisty 274(18), 12263-12268 (1999). 7.Balsinde, J.,Shinohara, H.,Lefkowitz, L.J., et al. Group V phospholipase A2-dependent inducation of cyclooxygenase-2 in macrophages. The Journal of Biological Chemisty 274, 25967-25970 (1999). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 430.4 |
| 分子式 | C22H27N2O5P |
| CAS号 | 164083-84-5 |
| 稳定性 | ≥ 2 years |
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