| 货号 | 17923-25g |
| 描述 | Naringenin (Item No. 14173) is a citrus-derived flavonoid that inhibits cytochrome P450 (CYP) 3A4 activity in human liver microsomes (IC50s = 139-188 μM).1,2 Naringin is a natural flavanone glycoside formed from naringenin and neohesperidose. It undergoes extensive metabolism in the liver, giving rise to naringenin and other bioactive metabolites that have anti-oxidant, anti-inflammatory, and anti-apoptotic effects.3 Naringin is a weak inhibitor of CYP3A4, providing 14% inhibition at 200 µM.2 It suppresses apoptosis in neurons and increases the expression of neurotrophic factor in dopaminergic neurons, providing neuroprotection.4 |
| 别名 | NSC 5548; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fuhr, U.,Klittich, K., and Staib, A.H. Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. British Journal of Clinical Pharmacology 35(4), 431-436 (1993). 2.Ho, P.C., and Saville, D.J. Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds. Journal of Pharmacy & Pharmaceutical Sciences 4(3), 217-227 (2001). 3.Bharti, S.,Rani, N.,Krishnamurthy, B., et al. Preclinical evidence for the pharmacological actions of naringin: A review. Planta.Med. 80, 437-451 (2014). 4.Jung, U.J.,Leem, E., and Kim, S.R. Naringin: A protector of the nigrostriatal dopaminergic projection. Exp.Neurobiol. 23(2), 124-129 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 580.5 |
| 分子式 | C27H32O14 |
| CAS号 | 10236-47-2 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |