| 货号 | 17913-1mg |
| 描述 | Tryptanthrin is an alkaloid tryptophan derivative originally isolated from various plants and found to have antimicrobial actions. Among its many actions in cells, it inhibits both 5-lipoxygenase and cyclooxygenase-2 (IC50s = 600 and 64 nM, respectively).1,2 Tryptanthrin suppresses angiogenesis in vivo and blocks signaling through VEGFR2 at the level of ERK1/2 signaling in vitro.3 It also prevents ERK signaling through Nrf2, reducing oxidative stress-induced hepatocytotoxicity.4 |
| 别名 | NSC 349447; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pergola, C.,Jazzar, B.,Rossi, A., et al. On the inhibition of 5-lipoxygenase product formation by tryptanthrin: Mechanistic studies and efficacy in vivo. British Journal of Pharmacology 165(3), 765-776 (2012). 2.Danz, H.,Stoyanova, S.,Wippich, P., et al. Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria. Planta.Med. 67(5), 411-416 (2001). 3.Liao, X.,Zhou, X.,Mak, N.K., et al. Tryptanthrin inhibits angiogenesis by targeting the VEGFR2-mediated ERK1/2 signalling pathway. PLoS One 8(12), (2013). 4.Moon, S.Y.,Lee, J.H.,Choi, H.Y., et al. Tryptanthrin protects hepatocytes against oxidative stress via activation of the extracellular signal-regulated kinase/NF-E2-related factor 2 pathway. Biological and Pharmaceutical Bullentin 37(10), 1633-1640 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 248.2 |
| 分子式 | C15H8N2O2 |
| CAS号 | 13220-57-0 |
| 稳定性 | ≥ 2 years |
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