| 货号 | 17911-25mg |
| 描述 | Hydroxychloroquine (HCQ) is a synthetic quinine derivative commonly used as an antimalarial drug.1 It is also useful in managing systemic lupus erythematosus, rheumatoid arthritis, and other diseases.2,3,1 HCQ inhibits autophagy and induces autophagic cell death (IC50 = 30 µM), suggesting potential applications in research and medicine.2,4,5,6 |
| 别名 | HCQ;NSC 4375; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ben-Zvi, I.,Kivity, S.,Langevitz, P., et al. Hydroxychloroquine: From malaria to autoimmunity. Clin. Rev. Allergy Immunol. 42(2), 145-153 (2012). 2.Yildirim-Toruner, C., and Diamond, B. Current and novel therapeutics in the treatment of systemic lupus erythematosus. J. Allergy Clin. Immunol. 127(2), 303-314 (2011). 3.Swierkot, J., and Szechinski, J. Methotrexate in rheumatoid arthritis. Pharmacol. Rep. 58(4), 473-492 (2006). 4.Boya, P.,González-Polo, R.A.,Casares, N., et al. Inhibition of macroautophagy triggers apoptosis. Mol.Cell Biol. 25(3), 1025-1040 (2005). 5.Ramser, B.,Kokot, A.,Metze, D., et al. Hydroxychloroquine modulates metabolic activity and proliferation and induces autophagic cell death of human dermal fibroblasts. Journal of Investigative Dermatology 129(10), 2419-2426 (2009). 6.Farrow, J.M.,Yang, J.C., and Evans, C.P. Autophagy as a modulator and target in prostate cancer. Nat.Rev.Urol. 11(9), 508-516 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 434 |
| 分子式 | C18H26ClN3O • H2SO4 |
| CAS号 | 747-36-4 |
| 稳定性 | ≥ 2 years |
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