| 货号 | 17910-100mg |
| 描述 | Aceclidine is an agonist of muscarinic receptors (EC50 = 1.8-17 µM for human M2).1 It induces contraction of iris sphincter muscle, resulting in miosis.2,3 Aceclidine has applications in glaucoma therapy and in basic research regarding muscarinic receptor signaling.1,2,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Griffin, M.T.,Figueroa, K.W.,Liller, S., et al. Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15. Journal of Pharmacology and Experimental Therapeutics 321(3), 1193-1207 (2007). 2.Ishikawa, H.,Desantis, L., and Patil, P.N. Selectivity of muscarinic agonists including (+/-)-aceclidine andantimuscarinics on the human intraocular muscles. Journal of Ocular Pharmacology and Therapeutics 14(4), 363-373 (1998). 3.Smith, S.A., and Smith, S.E. Factors determining the potency of cholinomimetic miotic drugs and their effect upon the light reflex in man. Br.J.Clin.Pharmac. 6, 149-153 (1978). 4.Shannon, H.E.,Hart, J.C.,Bymaster, F.P., et al. Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats. Journal of Pharmacology and Experimental Therapeutics 290(2), 901-907 (1999). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 205.7 |
| 分子式 | C9H15NO2 • HCl |
| CAS号 | 6109-70-2 |
| 稳定性 | ≥ 2 years |
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