| 货号 | 17885-1mg |
| 描述 | SCH 28080 is a reversible K+-competitive inhibitor of H+/K+-ATPases that is best known for its ability to block acid secretion through its action against the gastric H+/K+-ATPase (IC50 = 1.3 µM).1,2,3 It is effective against gastric H+/K+-ATPases from a variety of species and can inhibit colonic H+/K+-ATPases, but this activity appears to be species-dependent.4 SCH 28080 is also used to investigate the role of H+/K+-ATPases in non-mammalian organisms and to distinguish the actions of H+/K+-ATPases from other ATP-dependent transporters.5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Beil, W.,Hackbarth, I., and Sewing, K.F. Mechanism of gastric antisecretory effect of SCH 28080. Br.J.Pharmac. 88, 19-23 (1986). 2.Wallmark, B.,Briving, C.,Fryklund, J., et al. Inhibition of gastric H+,K+-ATPase and acid secretion by SCH 28080, a substituted pyridyl(1,2α)imidazole. The Journal of Biological Chemisty 262(5), 2077-2084 (1987). 3.Swarts, H.G.P.,Hermsen, H.P.H.,Koenderink, J.B., et al. Conformation-dependent inhibition of gastric H+,K+-ATPase by SCH 28080 demonstrated by mutagenesis of glutamic acid 820. Molecular Pharmacology 55, 541-547 (1999). 4.Shao, J.,Gumz, M.L.,Cain, B.D., et al. Pharmacological profiles of the murine gastric and colonic H,K-ATPases. Biochimica et Biophysica Acta 1800(9), 906-911 (2010). 5.Beane, W.S.,Morokuma, J.,Adams, D.S., et al. A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration. Chemistry & Biology 18, 77-89 (2011). 6.Salyer, S.A.,Olderding, J.R.,Distler, A.A., et al. Vacuolar ATPase driven potassium transport in highly metastatic breast cancer cells. Biochimica et Biophysica Acta 1832, 1734-1743 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 277.3 |
| 分子式 | C17H15N3O |
| CAS号 | 76081-98-6 |
| 稳定性 | ≥ 2 years |
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