| 货号 | 17877-1mg |
| 描述 | IAA-94 is an indanyloxyacetic acid (IAA) inhibitor of chloride channels that binds channels in bovine kidney cortex microsomes with a Ki value of 1 µM.1 At 10 µM, it also reversibly inhibits chloride intracellular channel proteins, which have both soluble and membrane-bound activities.2,3 IAA-94 is used to study the properties of chloride channels in a variety of preparations.4,5,3 |
| 别名 | R(+)-IAA 94; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Landry, D.W.,Reitman, M.,Cragoe, E.J., Jr., et al. Epithelial chloride channel. Development of inhibitory ligands. Journal of General Physiology 90, 779-798 (1987). 2.Valenzuela, S.M.,Mazzanti, M.,Tonini, R., et al. The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle. Journal of Physiology 529.3, 541-552 (2000). 3.Khamici, H.A.,Brown, L.J.,Hossain, K.R., et al. Memebers of the chloride intracellular ion channel protein family demonstrate glutaredoxin-like enzymatic activity. PLoS One 10(1), 1-19 (2015). 4.Costa, J.A.,Nguyen, D.A.,Leal-Pinto, E., et al. Wicking: A rapid method for manually inserting ion channels into planar lipid bilayers. PLoS One 8(5), 1-9 (2013). 5.Liskova, S.,Petrova, M.,Karen, P., et al. Contribution of Ca2+-dependent Cl- channels to norepinephrine-induced contraction of femoral artery is replaced by increasing EDCF contribution during ageing. BioMed Research International 289361, 1-9 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 357.2 |
| 分子式 | C17H18Cl2O4 |
| CAS号 | 54197-31-8 |
| 稳定性 | ≥ 2 years |
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