| 货号 | 17866-5mg |
| 描述 | 6-Sialyllactose consists of the monosaccharide N-acetylneuraminic acid (Item No. 16091) linked to the galactosyl subunit of lactose at the 6 position. This connection is at the 3 position in the related compound, 3’-sialyllactose (Item No. 16617). Both are major milk oligosaccharides that avidly bind several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus.1,2,3,4,5,6 These compounds can be used to differentiate and characterize the binding domains of viruses that recognize N-acetylneuraminic acid-capped cell surface receptors. They are also used as analytical reference standards for quantification in samples such as milk or colostrum. |
| 别名 | 6-N-Acetylneuraminyl-D-lactose; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Duncan, P.I.,Raymond, F.,Fuerholz, A., et al. Sialic acid utilisation and synthesis in the neonatal rat revisited. PLoS One 4(12), 1-10 (2009). 2.Sprenger, N., and Duncan, P.I. Sialic acid utilization. Adv.Nutr. 3(3), 392S-397S (2012). 3.Iskarpatyoti, J.A.,Morse, E.A.,McClung, R.P., et al. Serotype-specific differences in inhibition of reovirus infectivity by human-milk glycans are determined by viral attachment protein σ1. Virology 433(2), 489-497 (2012). 4.Neu, U.,Khan, Z.M.,Schuch, B., et al. Structures of B-lymphotropic polyomavirus VP1 in complex with oligosaccharide ligands. PLoS Pathogens 9(10), 1-10 (2013). 5.Rosa Borges, A.,Wieczorek, L.,Johnson, B., et al. Multivalent dendrimeric compounds containing carbohydrates expressed on immune cells inhibit infection by primary isolates of HIV-1. Virology 408(1), 80-88 (2010). 6.Wu, W., and Air, G.M. Binding of influenza viruses to sialic acids: Reassortant viruses with A/NWS/33 hemagglutinin bind to α2,8-linked sialic acid. Virology 325(2), 340-350 (2004). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 655.5 |
| 分子式 | C23H38NO19 • Na |
| CAS号 | 157574-76-0 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |