Tie2 Kinase Inhibitor
货号：
17858-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 17858-500ug |
| 描述 | Tunica interna endothelial cell kinase 2 (Tie2, also known as angiopoietin-1 receptor or tek) is an endothelium-specific receptor tyrosine kinase important for the development of embryonic vasculature and for angiogenesis and vascular maintenance in adult tissues.1 Tie2 kinase inhibitor reversibly and selectively blocks Tie2 kinase activity with an IC50 value of 250 nM.2 It is 200-fold more potent for inhibition of Tie2 compared to p38.2 Tie2 kinase inhibitor has been shown to reduce angiogenesis in a Matrigel neovascularization assay and to delay tumor growth in MOPC-315 plasmacytoma and SVR angiosarcoma xenograft models.2,3 |
| 别名 | Tunica Interna Endothelial Cell Kinase 2 Inhibitor; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wong, A.L.,Haroon, Z.A.,Werner, S., et al. Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. Circulation Research 81, 567-574 (1997).
2.Semones, M.,Feng, Y.,Johnson, N., et al. Pyridinylimidazole inhibitors of tie2 kinase. Bioorganic & Medicinal Chemistry Letters 17, 4756-4760 (2007).
3.Hasenstein, J.R.,Kasmerchak, K.,Buehler, D., et al. Efficacy of tie2 receptor antagonism in angiosarcoma. Neoplasia 14(2), 131-140 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 439.5 |
| 分子式 | C26H21N3O2S |
| CAS号 | 948557-43-5 |
| 稳定性 | ≥ 2 years |
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