BAM15
货号：
17811-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17811-1mg |
| 描述 | Typical mitochondrial uncouplers are lipophilic weak acids that increase proton transport into the mitochondrial matrix through an ATP synthase-independent pathway, thereby uncoupling nutrient oxidation from ATP production. These chemicals are used to determine rate of cellular respiration and have antioxidant effects that protect from ischemia-reperfusion injury. Most proton transporter uncouplers, however, exhibit off-target activity that can lead to undesired effects, including plasma membrane depolarization, mitochondrial inhibition, and cytotoxicity. BAM15 is a mitochondrial protonophore uncoupler that does not depolarize the plasma membrane and protects mice from acute renal ischemic-reperfusion injury.1 In comparison to FCCP (Item No. 15218), 1-10 µM BAM15 was shown to increase oxygen flux with equal potency as the classic uncoupler, while displaying a higher maximum rate of mitochondrial respiration and less cytotoxicity.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kenwood, B.M.,Weaver, J.L.,Bajwa, A., et al. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol.Metab. 3, 114-123 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 340.3 |
| 分子式 | C16H10F2N6O |
| CAS号 | 210302-17-3 |
| 稳定性 | ≥ 2 years |
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