| 货号 | 17809-1mg |
| 描述 | Pim-1 is a serine/threonine kinase that targets proteins involved in cell survival and proliferation and has roles in tumorigenesis.1,2 Pim-1 inhibitor 2 is a potent Pim-1 inhibitor (Ki = 91 nM) that targets the ATP-binding kinase hinge region.3,4,5 |
| 别名 | PIMi II; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Beharry, Z.,Mahajan, S.,Zemskova, M., et al. The Pim protein kinases regulate energy metabolism and cell growth. Proceedings of the National Academy of Sciences of the United States of America 108(2), 528-533 (2011). 2.Chen, J.,Kobayashi, M.,Darmanin, S., et al. Pim-1 plays a pivotal role in hypoxia-induced chemoresistance. Oncogene 28(28), 2581-2592 (2009). 3.Pierce, A.C.,Jacobs, M., and Stuver-Moody, C. Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase. Journal of Medicinal Chemistry 51(6), 1972-1975 (2008). 4.Duverger, A.,Wolschendorf, F.,Anderson, J.C., et al. Kinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivation. Journal of Virology 88(1), 364-376 (2014). 5.Brault, L.,Gasser, C.,Bracher, F., et al. PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers. Haematologica 95(6), 1004-1015 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 322.8 |
| 分子式 | C17H11CIN4O |
| CAS号 | 477845-12-8 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |