L-779,450
货号：
17807-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17807-1mg |
| 描述 | L-779,450 is an ATP-competitive B-Raf inhibitor (IC50 = 10 nM; Kd = 2.4 nM) that displays >7, >30, and >70-fold selectivity over p38α, GSK3β, and Lck, respectively.1 It has been shown to inhibit cell proliferation both in B-Raf mutated and wild-type melanoma cell lines, as well as to enhance tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in these cells.2 |
| 别名 | Raf Kinase Inhibitor IV; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Takle, A.K.,Brown, M.B.,Savies, S., et al. The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase. Bioorganic & Medicinal Chemistry Letters 18(15), 4373-4376 (2008).
2.Berger, A.,Quast, S.A.,Plötz, M., et al. RAF inhibition overcomes resistance to TRAIL-induced apoptosis in melanoma cells. Journal of Investigative Dermatology 134(2), 430-440 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 347.8 |
| 分子式 | C20H14ClN3O |
| CAS号 | 303727-31-3 |
| 稳定性 | ≥ 2 years |
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