| 货号 | 17797-1mg |
| 描述 | N-(p-Coumaroyl) serotonin is an antioxidative phenolic naturally found in plants, including safflower seed and millet grain.1,2 It ameliorates atherosclerosis in vivo, reducing lesion area in mice and rabbits.1,3N-(p-Coumaroyl) serotonin also suppresses inflammatory cytokine generation by human monocytes, augments fibroblast proliferation, and promotes relaxation of vascular smooth muscle cells in vitro.4,5,6 |
| 别名 | NSC 369503; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Katsuda, S.,Suzuki, K.,Koyama, N., et al. Safflower seed polyphenols (N-(p-coumaroyl)serotonin and N-feruloylserotonin) ameliorate atherosclerosis and distensibility of the aortic wall in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. Hypertens.Res. 32(11), 944-949 (2009). 2.Watanabe, M. Antioxidative phenolic compounds from Japanese barnyard millet (Echinochloa utilis) grains. Journal of Agricultural and Food Chemistry 47(11), 4500-4505 (1999). 3.Koyama, N.,Kuribayashi, K.,Seki, T., et al. Serotonin derivatives, major safflower (Carthamus tinctorius L.) seed antioxidants, inhibit low-density lipoprotein (LDL) oxidation and atherosclerosis in apolipoprotein E-deficient mice. J.Agric.Food Chem 54(14), 4970-4976 (2015). 4.Kawashima, S.,Hayashi, M.,Takii, T., et al. Serotonin derivative, N-(p-coumaroyl) serotonin, inhibits the production of TNF-α, IL-1α, IL-1β, and IL-6 by endotoxin-stimulated human blood monocytes. J.Interferon Cytokine Res. 18(6), 423-428 (1998). 5.Takii, T.,Hayashi, M.,Hiroma, H., et al. Serotonin derivative, N-(p-coumaroyl)serotonin, isolated from safflower (Carthamus tinctorius L.) oil cake augments the proliferation of normal human and mouse fibroblasts in synergy with basic fibroblast growth factor (bFGF) or epigermal growth factor (EGF). Journal of Biochemistry 125, 910-915 (1999). 6.Takimoto, T.,Suzuki, K.,Arisaka, H., et al. Effect of N-(p-coumaroyl)serotonin and N-feruloylserotonin, major anti-atherogenic polyphenols in safflower seed, on vasodilation, proliferation and migration of vascular smooth muscle cells. Mol.Nutr.Food Res. 55(10), 1561-1571 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 322.4 |
| 分子式 | C19H18N2O3 |
| CAS号 | 68573-24-0 |
| 稳定性 | ≥ 2 years |
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