| 货号 | 17793-50mg |
| 描述 | L-Selenocystine is a diselenide-bridged amino acid that may be confused with selenocysteine (Sec), which is a rare amino acid featuring a single selenium atom. L-Selenocystine is a redox-active selenium compound that has both anti- and pro-oxidant actions.1,2 This compound can be reduced by low molecular thiols and disulfide reductases to Sec. It is reduced to Sec by mammalian thioredoxin reductase (apparent Km = 6.0 µM), and this property can be used to assay thioredoxin reductase activity.2,3 L-Selenocystine induces an unfolded protein response, ER stress, and large cytoplasmic vacuolization in HeLa cells and has cytostatic effects in a range of cancer cell types.2,4 |
| 别名 | Seleno-L-cystine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Spallholz, J.E. On the nature of selenium toxicity and carcinostatic activity. Free Radical Biology & Medicine 17(1), 45-64 (1994). 2.Misra, S.,Boylan, M.,Selvam, A., et al. Redox-active selenium compounds--from toxicity and cell death to cancer treatment. Nutrients 7(5), 3536-3556 (2015). 3.Cunniff, B.,Snider, G.W.,Fredette, N., et al. A direct and continuous assay for the determination of thioredoxin reductase activity in cell lysates. Analytical Biochemistry 443(1), 34-40 (2013). 4.Wallenberg, M.,Misra, S.,Wasik, A.M., et al. Selenium induces a multi-targeted cell death process in addition to ROS formation. Journal of Cellular and Molecular Medicine 18(4), 671-684 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 334.1 |
| 分子式 | C6H12N2O4Se2 |
| CAS号 | 29621-88-3 |
| 稳定性 | ≥ 2 years |
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