| 货号 | 17769-1mg |
| 描述 | Spautin-1 is an autophagy inhibitor, inducing cell death in human breast cancer Bcap-37 cells grown in glucose-free media (EC50 = ~1.25 µM).1 It does not significantly affect the viability of Bcap-37 cells grown in complete media. Spautin-1 promotes the degradation of Vps34 PI3K complex by inhibiting the deubiquitinating enzymes USP10 and USP13 (IC50s = 0.58 and 0.69 µM, respectively).1 It is used to elucidate the role of autophagy in cellular processes.2,3 Spautin-1 has also been used to demonstrate roles for autophagy in viral infection.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Liu, J.,Xia, H.,Kim, M., et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 147, 223-234 (2011). 2.Salabei, J.K.,Cummins, T.D.,Singh, M., et al. PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress. Biochemistry Journal 451(3), 375-388 (2013). 3.Vakifahmetoglu-Norberg, H.,Kim, M.,Xia, H.g., et al. Chaperone-mediated autophagy degrades mutant p53. Genes & Development 27, 1718-1730 (2013). 4.Mateo, R.,Nagamine, C.M.,Spagnolo, J., et al. Inhibition of cellular autophagy deranges dengue virion maturation. J.Virology 87(3), 1312-1321 (2013). 5.Bouley, S.J.,Maginnis, M.S.,Derdowski, A., et al. Host cell autophagy promotes BK virus infection. Virology 456-457, 87-95 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 271.3 |
| 分子式 | C15H11F2N3 |
| CAS号 | 1262888-28-7 |
| 稳定性 | ≥ 2 years |
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