UPF-1069
货号：
17760-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17760-1mg |
| 描述 | The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. UPF-1069 is a PARP inhibitor that demonstrates a modest preference for PARP2 over PARP1 (IC50s = 0.3 and 8 µM, respectively).1 In rat models of post-ischemic brain damage, it has been shown to increase cell death in hippocampal slice cultures in a model characterized by loss of neurons through a caspase-dependent, apoptosis-like process but to be protective of cortical neurons in a model characterized by a necrosis-like process.2 |
| 别名 | GKT237841; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pellicciari, R.,Camaioni, E.,Costantino, G., et al. On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. Chem.Med.Chem. 3(6), 914-923 (2008).
2.Moroni, F.,Formentini, L.,Gerace, E., et al. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. British Journal of Pharmacology 157(5), 854-862 (2009).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 279.3 |
| 分子式 | C17H13NO3 |
| CAS号 | 1048371-03-4 |
| 稳定性 | ≥ 2 years |
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