GSK2193874
货号：
17715-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17715-1mg |
| 描述 | GSK2193874 is a potent antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist GSK634775 with IC50 values of 2, 5, and 40 nM for rat, mouse, and human isoforms, respectively.1 It is selective for TRPV4 over ~200 other human receptors, channels, and enzymes. GSK2193874 is effective in vivo, as it resolves pulmonary edema resulting from myocardial infarction in mice.1 TRPV4 blockade with GSK2193874 does not alter heart rate or blood pressure in rats, although it attenuates decreases in pulmonary and systemic arterial pressures induced by TRPV4 agonists.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Thorneloe, K.S.,Cheung, M.,Bao, W., et al. An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. Sci.Transl.Med. 4(159), (2012).
2.Pankey, E.A.,Kassan, M.,Choi, S.K., et al. Vasodilator responses to acetylcholine are not mediated by the activation of soluble guanylate cyclase or TRPV4 channels in the rat. American Journal of Physiology.Heart and Circulatory Physiology 306(11), 1495-1506 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 691.6 |
| 分子式 | C37H38BrF3N4O |
| CAS号 | 1336960-13-4 |
| 稳定性 | ≥ 2 years |
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