AH 7614
货号：
17713-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17713-1mg |
| 描述 | Free fatty acid receptor 4 (FFAR4/GPR120) is a G protein-coupled receptor expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.1,2 ω-3 Fatty acids, such as docosahexaenoic acid (Item No. 90310) and eicosapentaenoic acid (Item No. 90110), initiate FFAR4 signaling, resulting in inhibition of toll-like receptor and TNF-α inflammatory signaling pathways in a β-arrestin2/TAB1 dependent manner.2 AH 7614 is a selective FFAR4 antagonist (pIC50s = 7.1 versus< 4.6 for human FFAR4 and FFAR1 receptors, respectively).3 In U2OS osteosarcoma cells expressing the FFAR4 receptor, it has been shown to inhibit intracellular calcium accumulation induced by either linoleic acid or an FFAR4 agonist.3 |
| 别名 | NSC 31171;N-xanthen-9-yl-p-Toluenesulfonamide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Davenport, A.P.,Alexander, S.P.H.,Sharman, J.L., et al. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: Recommendations for new pairings with cognate ligands. Pharmacological Reviews 65(3), 967-986 (2013).
2.Oh, D.Y.,Talukdar, S.,Bae, E.J., et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin sensitizing effects. Cell 142(5), 687-698 (2010).
3.Sparks, S.M.,Chen, G.,Collins, J.L., et al. Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorganic & Medicinal Chemistry Letters 24, 3100-3103 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 351.4 |
| 分子式 | C20H17NO3S |
| CAS号 | 1616718 |
| 稳定性 | ≥ 2 years |
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