| 货号 | 17704-1mg |
| 描述 | Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.1,2,3 Dickkopf-1 (Dkk1) antagonizes Wnt signaling and has important roles in bone formation, cancer, and Alzheimer’s disease.4 WAY-262611 is an inhibitor of Dkk1 that activates the Wnt signaling pathway, stimulating β-catenin/TCF-dependent transcription with an EC50 value of 0.63 µM.5 It has good pharmacokinetic properties and increases trabecular bone formation in ovariectomized rats following oral administration.5 WAY-262611 has been used to elucidate the role of Dkk1 in modulating Wnt signaling, particularly in the context of arthritis.6,7 |
| 别名 | BML-WN110;Dickkopf-1 Inhibitor;Dkk1 Inhibitor; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Polakis, P. Wnt signaling and cancer. Genes & Development 14, 1837-1851 (2000). 2.Reya, T., and Clevers, H. Wnt signalling in stem cells and cancer. Nature 434, 834-850 (2005). 3.Clevers, H. Wnt/β-catenin signaling in development and disease. Cell 127, 469-480 (2006). 4.Hameed, A.,Brady, J.J.,Dowling, P., et al. Bone disease in multiple myeloma: pathophysiology and management. Cancer Growth Metastasis 7, 33-42 (2014). 5.Pelletier, J.C.,Lundquist, J.T.t.,Gilbert, A.M., et al. (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a winglessβcatenin agonist that increases bone formation rate. Journal of Medicinal Chemistry 52(22), 6962-6965 (2009). 6.Enochson, L.,Stenberg, J.,Brittberg, M., et al. GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition. Osteoarthritis Cartilage 22(4), 566-577 (2014). 7.Choe, Y.,Hun Kim, J.,Park, K.Y., et al. Activation of dickkopf-1 and focal adhesion kinase pathway by tumour necrosis factor α induces enhanced migration of fibroblast-like synoviocytes in rheumatoid arthritis. Rheumatology (Oxford) 29, (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 318.4 |
| 分子式 | C20H22N4 |
| CAS号 | 1123231-07-1 |
| 稳定性 | ≥ 2 years |
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