UNC2250
货号：
17703-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17703-1mg |
| 描述 | Tyro3, Axl, and Mer are members of the TAM family of receptor tyrosine kinases that have signaling roles in normal and malignant cells.1 UNC2250 is an inhibitor of Mer kinase activity, blocking the steady-state phosphorylation of endogenous Mer in 697 B-ALL cells with an IC50 value of 9.8 nM.2 It is selective for Mer over a panel of both tyrosine and serine-threonine kinases, including Tyro3 and Axl. UNC2250 also inhibits ligand-dependent phosphorylation of a chimeric EGFR-Mer protein and blocks colony formation in soft agar cultures of BT-12 rhabdoid tumor and Colo699 NSCLC cell lines.2 UNC2250 displays good pharmacokinetic properties in mice following intravenous or oral administration.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Verma, A.,Warner, S.L.,Vankayalapati, H., et al. Targeting Axl and Mer kinases in cancer. Molecular Cancer Therapeutics 10(10), 1763-1773 (2016).
2.Zhang, W.,Zhang, D.,Stashko, M.A., et al. Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. Journal of Medicinal Chemistry 56(23), 9683-9692 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 440.6 |
| 分子式 | C24H36N6O2 |
| CAS号 | 1493694-70-4 |
| 稳定性 | ≥ 2 years |
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