MM-102
货号：
17699-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17699-1mg |
| 描述 | WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.1 It serves as a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3 at lysine 4 to upregulate transcription.2 MM-102 is a potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM).3 It has been shown to block MLL1 methyltransferase activity, reducing the expression of HoxA9 and Meis-1 genes, which are both critical MLL1 target genes in MLL1 fusion protein-mediated leukemogenesis.3 MM-102 can also inhibit cell growth and induce apoptosis in leukemia cells harboring MLL1 fusion proteins.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Migliori, V.,Mapelli, M., and Guccione, E. On WD40 proteins: Propelling our knowledge of transcriptional control? Epigenetics 7(8), 815-822 (2012).
2.Guccione, E.,Bassi, C.,Casadio, F., et al. Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive. Nature 449, 933-937 (2007).
3.Karatas, H.,Townsend, E.C.,Cao, F., et al. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. Journal of the American Chemical Society 135(2), 669-682 (2013).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 669.8 |
| 分子式 | C35H49F2N7O4 |
| CAS号 | 1417329-24-8 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
