LH 846
货号：
17686-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17686-1mg |
| 描述 | LH 846 is a benzothiazole analog that selectively inhibits casein kinase (CK) 1δ (IC50 = 290 nM).1 It inhibits CK1ε and CK1α at much higher concentrations (IC50s = 1.3 and 2.5 μM, respectively) but does not inhibit CK2.1 LH 846 has been shown to inhibit CK1δ-dependent phosphorylation and degradation of PER1 protein and to lengthen the circadian period in U2OS cells.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lee, J.W.,Hirota, T.,Peters, E.C., et al. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angew Chem. Int. Ed. Engl. 50(45), 10608-10611 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 316.8 |
| 分子式 | C16H13ClN2OS |
| CAS号 | 639052-78-1 |
| 稳定性 | ≥ 2 years |
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