JAK2 Inhibitor V
货号：
17684-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17684-1mg |
| 描述 | Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 in which a switch from valine to phenylalanine occurs at the 617 position (V617F).1 JAK2 Inhibitor V is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2, displaying IC50 values between 10 and 30 µM.2 It has no effect on Tyk2 or c-Src kinase function. JAK2 Inhibitor V blocks the proliferation of erythroleukemia cells and human hematopoietic progenitor cells expressing JAK2-V617F.2 |
| 别名 | NSC 42834;Janus-Associated Kinase Inhibitor V;Z3; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gozgit, J.M.,Bebernitz, G.,Patil, P., et al. Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2. The Journal of Biological Chemisty 283(47), 32334-32343 (2008).
2.Sayyah, J.,Magis, A.,Ostrov, D.A., et al. Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth. Molecular Cancer Therapeutics 7(8), 2308-2318 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 344.5 |
| 分子式 | C23H24N2O |
| CAS号 | 195371-52-9 |
| 稳定性 | ≥ 1 year |
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