| 货号 | 17677-1mg |
| 描述 | The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. 5-fluoro 203 is a cytotoxic compound that at 1 µM activates AhR signaling, inducing transcription of CYP1A1, which leads to the formation of DNA adducts and cell cycle arrest.1,2,3 In certain ovarian, breast, kidney, and colorectal cancer cells, 5-fluoro 203 can increase the levels of reactive oxygen species as well as activate JNK, ERK, and p38 MAPK.4 |
| 别名 | 5F-203;NSC 703786; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brantley, E.,Patel, V.,Stinson, S.F., et al. The antitumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces NF-κB activity in drug-sensitive MCF-7 cells. Anti-Cancer Drugs 16(2), 137-143 (2005). 2.Hose, C.D.,Hollingshead, M.,Sausville, E.A., et al. Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: A potential surrogate marker for patient sensitivity. Molecular Cancer Therapeutics 2(12), 1265-1272 (2003). 3.Bruno, R.D., and Njar, V.C.O. Targeting cytochrome P450 enzymes: A new approach in anti-cancer drug development. Bioorganic & Medicinal Chemistry 15(15), 5074-5060 (2007). 4.Callero, M.A.,Luzzani, G.A.,De Dios, D.O., et al. Biomarkers of sensitivity to potent and selective antitumor 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F203) in ovarian cancer. Journal of Cellular Biochemistry 114(10), 2392-2404 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 258.3 |
| 分子式 | C14H11FN2S |
| CAS号 | 260443-89-8 |
| 稳定性 | ≥ 2 years |
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