IM-12
货号：
17673-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17673-1mg |
| 描述 | Glycogen synthase kinase 3β (GSK3β) is a constitutively active serine/threonine protein kinase implicated in several important regulatory processes. It can phosphorylate β-catenin, an intracellular signal transducer in the Wnt signaling pathway, which leads to β-catenin degradation. IM-12 is a non-symmetrically substituted indolylmaleimide that increases β-catenin levels by inhibiting GSK3β (IC50 = 53 nM).1,2 It has been shown to reduce proliferation and increase differentiation of a ReNCell VM cell line derived from human ventral midbrain.2 IM-12 is also reported to have a depolymerizing effect on in vitro tubulin assembly.3 |
| 别名 | GSK3β Inhibitor XIX; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Brennführer, A.,Neumann, H.,Pews-Davtyan, A., et al. Catalytic and stoichiometric synthesis of novel 3-aminocarbonyl-, 3-alkoxycarbonyl-, and 3-amino-4-indolylmaleimides. European Journal of Organic Chemistry 2009(1), 38-42 (2009).
2.Schmöle, A.C.,Brennführer, A.,Karapetyan, G., et al. Novel indolylmaleimide acts as GSK-3β inhibitor in human neural progenitor cells. Bioorganic & Medicinal Chemistry 18(18), 6785-6795 (2010).
3.Eisenlöffel, C.,Schmöle, A.C.,Pews-Davtyan, A., et al. Interference of a novel indolylmaleimide with microtubules induces mitotic arrest and apoptosis in human progenitor and cancer cells. Biochemical Pharmacology 85, 763-771 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 377.4 |
| 分子式 | C22H20FN3O2 |
| CAS号 | 1129669-05-1 |
| 稳定性 | ≥ 2 years |
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