WS6
货号：
17672-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17672-1mg |
| 描述 | WS6 is a compound that stimulates the proliferation of pancreatic β cells in rodent and human primary islets (ECmax = 200 and 400 nM, respectively, over four days).1,2 It promotes β cell growth in vivo, increasing β cell mass and normalizing blood glucose in the RIP-DTA mouse model of β cell ablation.1 WS6 also stimulates α cell proliferation in human pancreatic islets.3 WS6 appears to act by inhibiting IKKε and blocking the ability of EBP1 to suppress E2F-medtiated transcription.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Shen, W.,Tremblay, M.S.,Deshmukh, V.A., et al. Small-molecule inducer of β cell proliferation identified by highthroughput screening. J. Am. Chem. Soc. 135(5), 1669-1672 (2013).
2.Corritore, E.,Lee, Y.-S.,Sokal, E.M., et al. β-cell replacement sources for type 1 diabetes: A focus on pancreatic ductal cells. Therapeutic Advances in Endocrinology and Metabolism 7(4), 182-199 (2014).
3.Boerner, B.P.,George, N.M.,Mir, S.U.R., et al. WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability. Endocrine Journal 62(4), 379-386 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 568.6 |
| 分子式 | C29H31F3N6O3 |
| CAS号 | 1421227-53-3 |
| 稳定性 | ≥ 2 years |
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