Filgotinib
货号：
17669-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17669-1mg |
| 描述 | Filgotinib is a selective inhibitor of JAK1 (IC50 = 629 nM) that displays 30-fold selectivity for JAK1- over JAK2-dependent signaling in human whole blood.1,2,3 It potently blocks IL-6/STAT1 and IL-2/STAT5 signaling in cell models and whole blood assays.3 Filgotinib is converted to an active, JAK1-selective metabolite by carboxylesterases in vivo.2 |
| 别名 | GLPG 0634; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Menet, C.J.,Fletcher, S.R.,Van Lommen, G., et al. Triazolopyridines as selective JAK1 inhibitors: From hit identification to GLPG0634. Journal of Medicinal Chemistry 57, 9323-9342 (2014).
2.Namour, F.,Diderichsen, P.M.,Cox, E., et al. Pharmacokinetics and pharmacokinetic/pharmacodynamic modeling of filgotinib (GLPG0634), a selective JAK1 inhibitor, in support of phase IIB dose selection. Clinical Pharmacokinetics 54(8), 859-874 (2015).
3.Van Rompaey, L.,Galien, R.,van der Aar, E.M., et al. Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases. Journal of Immunology 191(7), 3568-3577 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 425.5 |
| 分子式 | C21H23N5O3S |
| CAS号 | 1206161-97-8 |
| 稳定性 | ≥ 2 years |
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