LEE011
货号：
17666-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 17666-500ug |
| 描述 | LEE011 is a cyclin-dependent kinase (CDK) inhibitor that targets cyclin D1/CDK4 and cyclin D3/CDK6 at nanomolar concentrations.1,2,3 It inhibits retinoblastoma protein phosphorylation, which prevents CDK-mediated G1-S phase transition, arresting the cell cycle in the G1 phase, suppressing DNA synthesis, and inhibiting cancer cell growth.3 LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC50 = 306 nM in sensitive lines).3 |
| 别名 | Ribociclib; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kim, S.,Loo, A.,Chopra, R., et al. LEE011: An orally bioavailable, selective small molecule inhibitor of CDK4/6 - Reactivating Rb in cancer. Molecular Cancer Therapeutics 12, (2013).
2.Dickson, M.A. Molecular pathways: CDK4 inhibitors for cancer therapy. Clinical Cancer Research 20(13), 3379-3383 (2014).
3.Rader, J.,Russell, M.R.,Hart, L.S., et al. Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clinical Cancer Research 19(22), 6173-6182 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 434.5 |
| 分子式 | C23H30N8O |
| CAS号 | 1211441-98-3 |
| 稳定性 | ≥ 2 years |
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