PF-431396
货号：
17665-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17665-1mg |
| 描述 | Proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK) are nonreceptor tyrosine kinases that constitute the focal adhesion kinase subfamily. PYK2 is expressed in both bone-forming osteoblasts and bone-resorbing osteoclasts where it has a positive role in osteoclast maturation and bone resorption. PF-431396 is a pyrimidine-based dual inhibitor of FAK and PYK2 (IC50s = 2 and 11 nM, respectively).1 In ovariectomized rats, it has been shown to increase bone formation, promoting osteoblast recruitment and activity.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Han, S.,Mistry, A.,Chang, J.S., et al. Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. The Journal of Biological Chemisty 284(19), 13193-13201 (2009).
2.Buckbinder, L.,Crawford, D.T.,Qi, H., et al. Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proceedings of the National Academy of Sciences of the United States of America 104(25), 10619-10624 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 506.5 |
| 分子式 | C22H21F3N6O3S |
| CAS号 | 717906-29-1 |
| 稳定性 | ≥ 2 years |
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