NI-57
货号：
17662-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17662-1mg |
| 描述 | The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators.1,2 BRPF1 (BR140 or Peregrin) is important for maintaining Hox gene expression and the development of multiple tissues, axial skeleton, and the hematopoietic system.2 NI-57 is a potent inhibitor of the bromodomains of BRPF proteins that binds to BRPF1B, BRPF2, and BRPF3 with Kd values of 31, 108, and 408 nM, respectively, as determined by isothermal titration calorimetry. It is selective for BRPFs over other bromodomains. NI-57 shows accelerated FRAP recovery at 1 µM in the BRPF2 FRAP assay, preventing binding of full-length BRPF2 to chromatin. See the Structural Genomics Consortium (SGC) website for more information. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ullah, M.,Pelletier, N.,Xiao, L., et al. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Mol.Cell Biol. 28(22), 6828-6843 (2008).
2.Klein, B.J.,Lalonde, M.E.,Côté, J., et al. Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes. Epigenetics 9(2), 186-193 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 383.4 |
| 分子式 | C19H17N3O4S |
| CAS号 | 1883548-89-7 |
| 稳定性 | ≥ 2 years |
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