GS-9973
货号：
17653-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17653-1mg |
| 描述 | Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation.1 GS-9973 is a potent Syk inhibitor (IC50 = 7.7 nM) that demonstrates 10-35-fold selectivity for Syk over a panel of 359 nonmutant kinases.2 In conjunction with the PI3Kδ inhibitor CAL-101 (Item No. 15279), it has been used to reduce chronic lymphocytic leukemia cell survival and to disrupt chemokine signaling at nanomolar concentrations.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Singh, R.,Masuda, E.S., and Payan, D.G. Discovery and development of spleen tyrosine kinase (SYK) inhibitors. Journal of Medicinal Chemistry 55(8), 3614-3643 (2012).
2.Currie, K.S.,Kropf, J.E.,Lee, T., et al. Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase. Journal of Medicinal Chemistry 57(9), 3856-3873 (2014).
3.Burke, R.T.,Meadows, S.,Loriaux, M.M., et al. A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor. Oncotarget 5(4), 908-915 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 411.5 |
| 分子式 | C23H21N7O |
| CAS号 | 1229208-44-9 |
| 稳定性 | ≥ 2 years |
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