SMI-481
货号：
17637-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17637-1mg |
| 描述 | Phosphatidylinositol (PtdIns) transfer proteins (PITPs) mediate the exchange of PtdIns and phosphatidylcholine between membranes, a step required for a wide array of cellular processes including cell division. SMI-481 is an inhibitor of the yeast PITP Sec14, blocking both Sec14-mediated transfer of [3H]-PtdInsin vitro and growth (IC50s = 0.21 and 2.87 µM, respectively).1 Suppression of Sec14 expression leads to proportional reduction in SMI-481 inhibition, suggesting that SMI-481 acts specifically through Sec14.1 Moreover, SMI-481 does not affect [3H]-PtdIns transfer mediated by other yeast PITPs.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nile, A.H.,Tripathi, A.,Yuan, P., et al. PITPs as targets for selectively interfering with phosphoinositide signaling in cells. Nature Chemical Biology 10(1), 76-84 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 363.8 |
| 分子式 | C17H15ClFN3O3 |
| CAS号 | 432020-20-7 |
| 稳定性 | ≥ 2 years |
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