LT175
货号：
17636-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17636-1mg |
| 描述 | Peroxisome proliferator-activated receptors (PPARs) are activated by fatty acids and eicosanoids as well as antidyslipidemic agents. Among the receptor isotypes, PPARα demonstrates a particular role in fatty acid oxidation whereas PPARγ is known to be involved in adipocyte differentiation and lipid storage. LT175 is a dual PPARα/γ ligand that displays partial agonism toward PPARγ (EC50s = 0.22, 0.26, and 0.48 µM for hPPARα, mPPARα, and hPPARγ, respectively).1 It exhibits low adipogenic activity in vitro and improves glucose homeostasis in diet-induced insulin resistant mice.1 LT175 was shown to disrupt the recruitment of coregulators, cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1, to PPARγ.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gilardi, F.,Giudici, M.,Mitro, N., et al. LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. J.Bio.Chem. 289(10), 6908-6920 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 318.4 |
| 分子式 | C21H18O3 |
| CAS号 | 862901-87-9 |
| 稳定性 | ≥ 2 years |
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