MN-64
货号：
17635-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17635-1mg |
| 描述 | Tankyrases (TNKS) are poly-ADP-ribosyltransferases, which cleave NAD+ to produce nicotinamide and ADP-ribose, which is then covalently attached to an acceptor protein in a process known as poly(ADP-ribosyl)ation. MN-64 is a potent inhibitor of TNKS1 and TNKS2 (IC50s = 6 and 72 nM, respectively).1 It is ineffective against several poly(ADP-ribosyl) polymerases (IC50 > 19 µM). Through its effects on TNKS, MN-64 inhibits signaling along the Wnt/β-catenin pathway in a cell-based reporter assay.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Narwal, M.,Koivunen, J.,Haikarainen, T., et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. Journal of Medicinal Chemistry 56(20), 7880-7889 (2013).
2.Haikarainen, T.,Krauss, S., and Lehtiö, L. Tankyrases: Structure, function, and therapeutic implications in cancer. Current Pharmaceutical Design 20, 6472-6488 (2014).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 264.3 |
| 分子式 | C18H16O2 |
| CAS号 | 92831-11-3 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
