ML-345
货号：
17633-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17633-1mg |
| 描述 | Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling.1 In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer’s disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM.2 It demonstrates 10-fold selectivity for IDE over a panel of enzymes with reactive cysteine residues.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Maianti, J.P.,McFedries, A.,Foda, Z.H., et al. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature 511(7507), 94-98 (2014).
2.Bannister, T.D.,Wang, H.,Abdul-Hay, S.O., et al. ML345, a small-molecule inhibitor of the insulin-degrading enzyme (IDE). 1 R03 DA024888-01 (MLSCN cycle 6), 1-41 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 479.5 |
| 分子式 | C21H22FN3O5S2 |
| CAS号 | 1632125-79-1 |
| 稳定性 | ≥ 2 years |
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