P11
货号：
17507-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 17507-500ug |
| 描述 | Lipoprotein-associated phospholipase A2, also known as platelet activating factor acetylhydrolase (PAF-AH) or phospholipase A2 group 7, hydrolyzes glycerophospholipids to produce lyso-PAF/lyso-phosphatidylcholine and short and/or oxidized fatty acids, many of which have pro-inflammatory or pro-oxidative activities. PAF-AH1b2 and 1b3 form a complex with 1b1 to regulate brain development, spermatogenesis, and cancer pathogenesis. P11 is an inhibitor of PAF-AH1b2- and 1b3-mediated hydrolysis of PAF to lyso-PAF (IC50s = 37 and 880 nM, respectively) without significant effect on other brain serine hydrolases.1 At 10 µM, it has been shown to impair Neuro2a and PC3 tumor cell survival.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chang, J.W.,Zuhl, A.M.,Speers, A.E., et al. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. ACS Chemical Biology (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 503.7 |
| 分子式 | C30H33NO4S |
| CAS号 | 942285-55-4 |
| 稳定性 | ≥ 2 years |
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