| 货号 | 17499-500ug |
| 描述 | CL 316,243 is a β3-adrenoceptor agonist (EC50 = 3 nM) that is >10,000-fold selective over β1 and β2.1,2 It causes a rapid decrease in blood glucose level in mice and has been used to study the induction of brown adipocytes and to increase thermogenesis in a mouse model of dietary obesity.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bloom, J.D.,Dutia, M.D.,Johnson, B.D., et al. Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent β-adrenergic agonist virtually specific for β3 receptors. A promising antidiabetic and antiobesity agent. Journal of Medicinal Chemistry 35(16), 3081-3084 (1992). 2.Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005). 3.Guerra, C.,Koza, R.A.,Yamashita, H., et al. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. Journal of Clinical Investigation 102(2), 412-420 (1998). 4.MacPherson, R.E.K.,Castellani, L.,Bueadoin, M.S., et al. Evidence for fatty acids mediating CL 316,243-induced reductions in blood glucose in mice. American Journal of Physiology.Endocrinology and Metabolism 307(7), E563-E570 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 465.8 |
| 分子式 | C20H18ClNO7 • 2Na |
| CAS号 | 138908-40-4 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |