| 货号 | 17476-500ug |
| 描述 | Protein kinase Cɛ (PKCɛ) is a calcium-independent, phospholipid- and diacylglycerol-dependent serine/threonine kinase involved in diverse signaling pathways, including those involved in neuronal signaling, cytoskeletal function, and inflammation.1 PKCɛ inhibitor peptide is a synthetic peptide corresponding to an amino acid sequence found in the amino terminal C2 domain of most mammalian forms of PKCɛ.2 It selectively and reversibly inhibits the translocation of PKCɛ to intracellular membranes, blocking activation.2 PKCɛ inhibitor peptide is commonly used in cells to evaluate the role of PKCɛ in various cellular responses.3,4,5 |
| 别名 | Protein Kinase Cɛ Inhibitor Peptide;ɛV1-2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Toker, A. Signaling through protein kinase C. Frontiers in Bioscience 3, d1134-d1147 (1998). 2.Johnson, J.A.,Gray, M.O.,Chen, C.H., et al. A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function. The Journal of Biological Chemisty 271(40), 24962-24966 (1996). 3.Schuster, D.J.,Kitto, K.F.,Overland, A.C., et al. Protein kinase Cε is required for spinal analgesic synergy between delta opioid and alpha-2A adrenergic receptor agonist pairs. Journal of Neuroscience 33(33), 13538-13546 (2013). 4.Thomspon, J.W.,Dave, K.R.,Saul, I., et al. Epsilon PKC increases brain mitochondrial SIRT1 protein levels via heat shock protein 90 following ischemic preconditioning in rats. PLoS One 8(9), 1-12 (2013). 5.Obis, T.,Besalduch, N.,Hurtado, E., et al. The novel protein kinase C epsilon isoform at the adult neuromuscular synapse: Location, regulation by synaptic activity-dependent muscle contraction through TrkB signaling and coupling to ACh release. Mol.Brain (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 844 |
| 分子式 | C37H65N9O13 |
| CAS号 | 182683-50-7 |
| 稳定性 | ≥ 2 years |
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