ML-324
货号：
17472-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17472-1mg |
| 描述 | The family of Jumonji domain containing histone demethylases 2 (JMJD2s, also known as KDM4s) demethylates lysines 9 and 36 on histone 3, resulting in the repression of specific mammalian and viral genes.1 ML-324 is a cell-permeable inhibitor of JMJD2E (KDM4DL; IC50 = 920 nM) that is inactive against lysine-specific demethylase, LSD1.2,3 It reduces the expression of immediate early genes of Herpes simplex virus (IC50 = ~10 µM) and human cytomegalovirus, blocks viral infection, and suppresses the level of viral reactivation in a ganglia explant model of latently infected mice.2 The effects of ML-324 are reversible, as viral replication resumes after drug withdrawal.2 |
| 别名 | CID-44143209; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hillringhaus, L.,Yue, W.W.,Rose, N.R., et al. Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. The Journal of Biological Chemisty 286(48), 41616-41625 (2011).
2.Liang, Y.,Vogel, J.L.,Arbuckle, J.H., et al. Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency. Sci.Transl.Med. 5(167), 1-10 (2013).
3.Rai, G.,Kawamura, A.,Tumber, A., et al. Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity. MH084681, 1-32 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 349.4 |
| 分子式 | C21H23N3O2 |
| CAS号 | 1222800-79-4 |
| 稳定性 | ≥ 2 years |
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