| 货号 | 17416-1mg |
| 描述 | SB-258585 is a potent, selective antagonist of the serotonin 5-HT6 receptor (pKi = 8.53).1 It displays over 100-fold selectivity for 5-HT6 over other 5-HT, dopamine, and α-adrenergic receptors. Radiolabeled forms of SB-258585 have been used to evaluate other potential ligands of the 5-HT6receptor.2 SB-258585 has been used in cells and in animals to evaluate the role of the 5-HT6 receptor in diverse processes.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hirst, W.D.,Minton, J.A.L.,Bromidge, S.M., et al. Characterization of [125I]-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue. British Journal of Pharmacology 130(7), 1597-1605 (2000). 2.Routledge, C.,Bromidge, S.M.,Moss, S.F., et al. Characterization of SB-271046: A potent, selective and orally active 5-HT6 receptor antagonist. British Journal of Pharmacology 130, 1606-1612 (2000). 3.Tatara, A.,Shimizu, S.,Shin, N., et al. Modulation of antipsychotic-induced extrapyramidal side effects by medications for mood disorders. Prog.Neuropsychopharmacol.Biol.Psychiatry 38, 252-259 (2012). 4.Duhr, F.,Déléris, P.,Raynaud, F., et al. Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth. Nature Chemical Biology 10, 590-597 (2014). 5.Shumizu, S.,Mizuguchi, Y.,Sobue, A., et al. Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in mice. J. Pharmacol. Sci. 127(4), 439-445 (2015). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 523.8 |
| 分子式 | C18H22IN3O3S • HCl |
| CAS号 | 1216468-02-8 |
| 稳定性 | ≥ 2 years |
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