AZD 8186
货号：
17384-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17384-1mg |
| 描述 | AZD 8186 is a selective PI3Kβ/δ inhibitor that exhibits IC50 values of 3, 17, and 752 nM for PI3Kβ, δ, and α, respectively, in cells sensitive to isoform-specific PI3K inhibition.1,2 It shows no significant binding against a panel of 442 other kinases when tested at a concentration of 10 µM and exhibits high oral efficacy in mouse cancer models.1 AZD 8186 inhibits growth of a range of cell lines, with preferential activity in cells with PTEN mutation or deficiency, and inhibits growth of prostate and triple negative breast cancer tumors in vivo, both as a single agent and in combination with docetaxel (Item No. 11637).2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Barlaam, B.,Cosulich, S.,Degorce, S., et al. Discovery of (R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): A potent and selective inhibitor of PI3Kβ and PI3Kδ for the treatment of PTEN-deficient cancers. J. Med. Chem. 58(2), 943-962 (2015).
2.Hancox, U.,Cosulich, S.,Hanson, L., et al. Inhibition of PI3Kβ signaling with AZD8186 inhibits growth of PTEN-deficient breast and prostate tumors alone and in combination with docetaxel. Mol. Cancer Ther. 14(1), 48-58 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 457.5 |
| 分子式 | C24H25F2N3O4 |
| CAS号 | 1627494-13-6 |
| 稳定性 | ≥ 2 years |
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